Active Pharmaceutical Intermediates Ingredients

CAS # 109887-53-8

H. S. NO. 29333990

END USE: PAROXETINE HCL

Molecular Formula: C13H18FNO

Molecular Wt.: 223.29

Sr. No. Test Standard Specification
01 Appearance White to Yellowish crystalline Powder.
02 Melting Point Between 96°C to 102°C.
03 Loss on Drying Not More Than 0.50%.
04 Specific rotation (at 20°C +2°C) Between -34°C to -38°.
05 Assay by HPLC Not Less Than 98.0%.
06 Chromatographic Purity Not Less Than 98.0%.
07 Related Substance by HPLC
Known Impurity 1 Not More Than 0.10%.
Known Impurity 2 Not More Than 0.5%.
Any Other Individual
unknown impurity
Not More Than 0.5%.
Total Impurities Not More Than 2.0%.
08 Content of (4) Enantiomer Not More Than 0.7%.
Remarks: The above-referred product NPP-5 complies as per In-house Specifications.
Storage condition: Store in a tightly closed container at a room temperature.

CAS # 50910-55-9

H. S. NO. 29223900

END USE: AMBROXOL HCL

Molecular Formula: C7H5Br2NO

Molecular Wt.: 278.93

Sr. No. Test Standard Specification
01 Description Yellow coloured crystalline powder.
02 Solubility Sparingly soluble in chloroform i.e. 2.0%w/v solution in chloroform must be clear.
03 Identification
By HPLC In the test of assay Retention time of the principal peak in sample preparation should be corresponds to that peak of the standard preparation.
04 Melting point Between 137 to 140°C.
05 Loss on drying @105°C Not more than 0.5%,
06 Related Substance by HPLC
2-amino-3,5 dibromo benzoic acid Not more than 0.10%
2-amino-3,5 dibromo benzyl alcohol Not more than 0.10%
Each unspecified impurity Not more than 0.10%
Total Impurities Not more than 0.50%
07 Purity by HPLC Not Less Than 99.50%
08 Assay by HPLC (OAB) 98.0 to 102.0%
Remarks: The above-referred product 2-amino 3,5-Dibromo benzaldehyde (NPP-9) complies as per In-house Specifications. Storage condition: Store in a tightly closed container.

CAS # 79560-19-3

H. S. NUMBER: 29269095

END USE: SERTRALINE HCL

Molecular Formula: C6H12Cl2O

Molecular Wt.: 291.17

Sr. No. Test Standard Specification
01 Description A white to off white crystalline powder.
02 Solubility Slightly soluble in water
03 Identification Infrared absorption
By IR The IR spectrum of sample must be concordant with spectrum of the working standard.
By HPLC In the test of assay retention time of the principal peak in sample preparation should be corresponds to that peak of the standard preparation.
04 Melting Point About 100°C.
05 Loss on drving 70°C Not more than 0.5%.
06 Related substances by HPLC
2,3-Dichloro isomer of This email address is being protected from spambots. You need JavaScript enabled to view it. RRT Not more than 0.10%
Unspecified impurities (any single) Not more than 0.10%
Total Impurities Not more than 0.50%
07 Sulphated Ash Not more than 0.10%
08 Purity by HPLC Not less than 99.50%
09 Assay by HPLC 99.0 to 102.0% on dried basis
10 Residual solvent
Methanol Not More than 3000 ppm
Acetone Not more than 5000 ppm
1,2 Dichlorobenzene Not more than 360 ppm
Remarks: The above referred product NPP-14 complies as per in-house Specifications.
Storage condition: Store in tightly closed container at Room Temperature